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目的研究胃酸分泌和粘膜萎缩对胃体和胃窦幽门螺杆菌（ Hp）定植的影响。方法将 95例 Hp阳性的慢性萎缩性胃炎患者分组。组一：胃窦中度萎缩伴胃体轻、中或重度萎缩性胃炎；组二：胃体轻度萎缩伴胃窦轻、中或重度萎缩性胃炎。分别测定基础酸分泌、最大酸分泌和胃泌素， Warthin-Starry染色诊断 Hp，同一组织诊断萎缩并分度。内因子抗体阳性者除外。结果组一中胃窦萎缩固定不变的各组之间，酸分泌显著降低组胃窦部 Hp定植率显著降低（ P< 0.05）；组一中胃体萎缩中度与重度组比较，最大酸分泌差异无统计学意义 (P >0.05)，胃体重度萎缩组 Hp定植率较中度萎缩组明显低下 (P< 0.05)。组二中胃体萎缩固定不变的各组之间，酸分泌显著降低组胃体 Hp定植率显著降低 (P< 0.05)；组二中胃窦萎缩中度与重度组比较，基础酸、最大酸分泌差异无统计学意义 (P >0.05)，胃窦重度萎缩组 Hp定植率较中度萎缩组明显低下（ P< 0.05）。结论慢性萎缩性胃炎的低酸和萎缩明显影响胃窦、体部 Hp的定植，两种影响因素既独立又互补。
Objective To study the effects of gastric acid secretion and mucosal atrophy on the colonization of Helicobacter pylori (Hp) in the gastric and gastric antrum. Methods 95 patients with Hp-positive chronic atrophic gastritis were divided into groups. Group A: moderate antral atrophy with gastric light, moderate or severe atrophic gastritis; Group two: mild gastric body with atrophic gastritis mild, moderate or severe atrophic gastritis. The basal acid secretion, maximal acid secretion and gastrin were measured. Warthin-Starry staining was used to diagnose Hp. The same tissue was diagnosed atrophy and indexed. Except for the internal factor antibody positive. Results In group A, the atrophy of gastric antrum was unchanged in all groups, and the secretion of Hp in gastric antrum significantly decreased in group A (P <0.05) There was no significant difference in secretion between two groups (P> 0.05). Hp colonization rate was significantly lower in patients with severe atrophic gastritis than in moderate atrophy (P <0.05). In Group 2, the gastric acid secretion was significantly decreased (P <0.05) between groups with unchanged gastric atrophy (P <0.05). Group 2 showed moderate atrophy of gastric antral in comparison with severe group There was no significant difference in acid secretion (P> 0.05). Hp colonization rate in patients with severe antral atrophy was significantly lower than that in moderate atrophy group (P <0.05). Conclusion Low acid and atrophy of chronic atrophic gastritis significantly affect the colonization of gastric antrum and body Hp. Both of the two influencing factors are independent and complementary.