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目的:观察消黄散对实验性黄疸大鼠一氧化氮(NO)、内皮素(ET) 的影响。方法:采用一次性灌胃异硫氰酸α-萘酯(ANIT)中毒制备大鼠黄疸模型,不同剂量消黄散为治疗组,与思美泰对照,观察血清NO、ET及谷丙转氨酶(ALT)、总胆红素(TBil)、γ-谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)及肝组织病理变化。结果:消黄散能降低病理性升高的NO水平,恢复ET正常水平,并能显著改善相关指标(P<0.01),消黄散中、大剂量在某些方面优于思美泰(P<0.01)。结论:消黄散对NO、ET有显著的调节作用,从而改善微循环,促进肝损伤的修复,促进胆红素的正常摄入和排泄。
Objective: To observe the effect of Xiaohuangsan on nitric oxide (NO) and endothelin (ET) in experimental jaundice rats. METHODS: A rat model of jaundice was prepared by single-dose intragastric administration of α-naphthyl isothiocyanate (ANIT) poisoning. Xiaohuang powder of different doses was used as the treatment group. The levels of serum NO, ET and alanine aminotransferase were observed after treatment with Smeite. ALT), total bilirubin (TBil), γ-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), and pathological changes in liver tissue. RESULTS: Xiaohuangsan can reduce the pathologically elevated NO level, restore normal ET level, and significantly improve the related indexes (P<0.01). Xiaozhong Powder’s middle and high doses are superior to Smetai in some aspects (P<0.01). ). Conclusion: Xiaohuangsan can significantly regulate NO and ET, thus improving microcirculation, promoting liver injury repair, and promoting normal bilirubin uptake and excretion.