癫痫是一种病因很复杂的神经系统临床综合症,对于其病因多年来从生理、生化、遗传等各个角度进行了深入的探讨.但迄今相当数量的原发性癫痫病因仍然不清,许多继发性癫痫虽已知其病因,但发病的机转仍属不明.目前认识到,惊厥的发生是脑神经细胞异常放电的结果,但异常放电的物质基础是什么,目前仍在探索之中.近十年来,随着免疫学的飞速发展,在从基础到临床的各个领域内,从免疫学的角度对癫痫的免疫病因进行了一些探讨,现综述如下:动物实验:早在1942年就曾发现过敏及免疫机制可以引起实验动物脑组织的异常放电及惊厥发 Epilepsy is a complicated clinical syndrome of the nervous system, and its etiology has been explored from various aspects of physiology, biochemistry and genetics for many years, but so far a considerable number of causes of primary epilepsy remain unclear. Epilepsy is known although its cause, but the pathogenesis is still unknown.Currently recognized that the occurrence of convulsions is the result of abnormal discharge of brain cells, but the material basis of abnormal discharge is still under investigation. In the past ten years, with the rapid development of immunology, in the basic and clinical fields, from the immunological point of view of the immune etiology of epilepsy are summarized, are summarized as follows: Animal experiments: as early as 1942 once Found that allergic and immune mechanisms can cause abnormal discharge of experimental animal brain tissue and convulsions