早在公元前400年,Hippocraters氏指出在黄疸病人中出现的黄疸是胆汁色素的过量积蓄造成的,但是有关胆色素的知识进展还是近代开始的。1845年Scher氏从黄疸病人尿液中提取了一种胆绿素的粗品(是胆红素的氧化产物),1864年Staedeler从结石中首先成功地提取了胆红素,尔后,Gibson等人和Libowitzky先后从猪胆汁和牛胆汁中分离出胆红素,30年代末Jules D.等获得 As early as 400 BC, Hippocraters pointed out that the occurrence of jaundice in patients with jaundice is caused by the excessive accumulation of bile pigments, but the knowledge about bile pigments has been developed in modern times. In 1845, Scher extracted a crude bilirubin from the urine of a patient with jaundice (which is an oxidation product of bilirubin). In 1864, Staedeler first successfully extracted bilirubin from stones, and later Gibson et al. Libowitzky isolated bilirubin from pig bile and bovine bile, obtained by Jules D. et al.