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作者为了了解每日一次服周效磺胺后,血清中周效磺胺的浓度变化情况,以及能否维持有效。在使用周效磺胺1,500毫克和乙胺嘧啶75毫克复方预防疟疾的现场实验中,选择6个成人作为取血对象,实验连续8～9个月,取血时间均在每二次服药后的第3小时,第7、14和28天。血清中周效磺胺的测定方法是采用Bratton和Marshall的方法。血清中周效磺胺浓度的测定结果。:第3小时内血浓度均为19.9±2.4(SD)毫克/100毫升,第14天下降为6.2±2.8毫克/
In order to understand the daily sulfa sulfonylureas, serum concentrations of sulfadox psoxacin changes, and can maintain effective. Sixty-five adults were enrolled in this field trial using a combination of sulfasalazine (1,500 mg) and pyrimethamine (75 mg) in the prevention of malaria. The duration of the experiment was 8 to 9 months, 3 hours, days 7, 14 and 28. Determination of psoason in serum was performed using the method of Bratton and Marshall. Determination of serum sulfonamides concentration results. : The first three hours of blood concentrations were 19.9 ± 2.4 (SD) mg / 100 ml, the first 14 days decreased to 6.2 ± 2.8 mg /