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目的探讨纤维蛋白原(Fib)在急性脑血管病(CVD)中的变化及其临床应用价值。方法 95例研究对象,其中脑出血(intracerebral hemorrhage,ICH)组19例,脑梗死(cerebral infarction,CI)组42例;同期入院非脑血管病(non cerebral vascular disease,Non-CVD)患者34例。测定Fib水平,分析Fib在急性CVD时的变化和临床价值。结果 ICH组Fib含量增高明显(3.90±0.55),较CI组(3.28±1.13)及Non-CVD组(2.98±0.46)相比差异均有统计学意义(P<0.05),CI组与ICH组相比差异有统计学意义(P<0.05),与Non-CVD组比较差异无统计学意义(P>0.05)。结论血浆Fib参与了动脉粥样硬化及急性CVD的病理生理过程,在急性CVD的辅助诊断中具有一定的运用价值。
Objective To investigate the changes of fibrinogen (Fib) in acute cerebrovascular disease (CVD) and its clinical value. Methods A total of 95 subjects were enrolled in this study. Among them, 19 were intracerebral hemorrhage (ICH) and 42 were cerebral infarction (CI). 34 patients with non-cerebral vascular disease (non-CVD) . Fib levels were measured and the changes and clinical value of Fib in acute CVD were analyzed. Results Compared with CI group (3.28 ± 1.13) and Non-CVD group (2.98 ± 0.46), the content of Fib in ICH group increased significantly (3.90 ± 0.55) (P <0.05) Compared with Non-CVD group, there was no significant difference (P> 0.05). Conclusion Plasma Fib is involved in the pathophysiological process of atherosclerosis and acute CVD and has certain value in the diagnosis of acute CVD.