Objective To evaluate the effect of Ginsenoside Re on Shock through different animal models in order to provide preclinical pharmacological experimental data.Methods In superior mesenteric artery occlusion(SMAO)of rats model was established by clamping superior mesenteric artery(SMA)for 2 hours and then reperfusing for another 2 hours.During the whole process mean artery pressure(MAP)and heart rate(HR)were recorded.The blood samples were collected before and 2 hours after clamping respectively,to determine serum GOT,GPT,LDH,GLU,CK,BUN,Cr and NO.Intestine,lung,heart,kidney and liver tissue samples were also collected after reperfusion 2 hours,and(1)protein concentration of bronchia alveolus lung fluid [BALF],(2)HSP70 expression in heart and kidney(3)histology pathology and(4)oxidation injury(MDA and GSH-Px)in above tissues were determined.Hemorrhagic shock(HS)of cats,scald shock model and insulin shock model were also introduced here.Results Ginsenoside Re decreased the morality of SMAO rats and the GOT,GPT,LDH,CK,BUN,NO and Cr level,the GSH-Px activity was increased and MDA content was decreased.The expression of HSP70 in heart and kidney were up-regulated and the protein content in BALF was inhibited after Ginsenoside Re treatment.Ginsenoside Re corrected acidosis induced by HS,and elevated Hb content,reduced serum MDA,LD level.Ginsenoside Re could attenuate liver and lung tissue injury.In scald shock,Ginsenoside Re decreased LDH,CK-MB,a-HBD and Hct of serum and in insulin shock survival time was prolonged.Conclusions Ginsenoside Re showed an anti-shock activity. Objective To evaluate the effect of Ginsenoside Re on Shock through different animal models in order to provide preclinical pharmacological experimental data.Methods In superior mesenteric artery occlusion(SMAO)of rats model was established by clamping superior mesenteric artery(SMA) for 2 hours and then The reperfusing for another 2 hours. During the whole process mean artery pressure (MAP) and heart rate (HR) were recorded. The blood samples were collected before and 2 hours after binding respectively, to determine serum GOT, GPT, LDH, GLU, CK ,BUN,Cr and NO.Intestine,lung,heart,kidney and liver tissue samples were also collected after reperfusion 2 hours,and(1)protein concentration of bronchia alveolus lung fluid [BALF],(2)HSP70 expression in heart and kidney (3) Histology pathology and (4) oxidation injury (MDA and GSH-Px) in above structures were determined. Hemorrhagic shock (HS) of cats, scald shock model and insulin shock model were also introduced here.Results Ginsenoside Re declined the morality Of SMAO Rats and the GOT, GPT, LDH, CK, BUN, NO and Cr level, the GSH-Px activity was increased and MDA content was decreased. The expression of HSP70 in heart and kidney were up-regulated and the protein content in BALF was Inhibited after Ginsenoside Re treatment.Ginsenoside Re cheerful acidosis induced HS,and elevated Hb content,reduced serum MDA,LD level.Ginsenoside Re could attenuate liver and lung tissue injury.In scald shock,Ginsenoside Re decreased LDH,CK-MB,a -HBD and Hct of serum and in insulin shock survival time was prolonged.Conclusions Ginsenoside Re showed an anti-shock activity.