泌尿系统肿瘤是威胁男性健康的最常见的恶性肿瘤。肿瘤的发生发展是多种基因参与的细胞增殖与凋亡平衡的过程。Survivin是凋亡抑制蛋白家族(inhibitor of apoptosis proteins,IAP)的成员之一,它的主要功能是抑制细胞凋亡和促进细胞增殖,具有在正常组织中低表达,在恶性肿瘤组织中高表达的特异性。Survivin可作为泌尿系统肿瘤的早期诊断和预后判断指标,也可作为肿瘤治疗的新靶点。 Urinary system tumors are the most common malignancies that threaten men’s health. The occurrence and development of tumors is a process in which a variety of genes are involved in cell proliferation and apoptosis balance. Survivin is a member of the inhibitor of apoptosis proteins (IAPs). Its main function is to inhibit apoptosis and promote cell proliferation. Survivin is characterized by low expression in normal tissues and high expression in malignant tumors Sex. Survivin can be used as an indicator of early diagnosis and prognosis of urological tumors, as well as a new target of tumor therapy.