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针对乙型肝炎病毒(HBV)持续感染与宿主免疫功能低下有关的理论,我们于1992～1993年对慢性乙型肝炎病毒携带者儿童注射乙肝免疫球蛋白及乙型肝炎疫苗,同时,给对照组患儿口服灭奥宁等治疗进行对照。现将两组治疗效果报道如下。 资料与方法 一、临床资料:该组患儿均为门诊病例,均因轻度纳差、疲乏、面色苍白等原因而就诊,经实验室检查,乙型肝炎五项标志(ELISA法)HBsAg、HBeAg、抗-HBc均为阳性,肝功能正常,肝脾无明显肿大。选择400例将其分为2组,每组200例,病程6个月～8年;年龄3/2～14岁。治疗组:男120例,女80例,3/2～3岁61例,～7岁80例,～14岁59例。对照组:男108例,女92例,3/2～3岁58例。～7岁82例,～14岁60例。两组的年龄,乙型肝炎五项标志及临床表现等均相仿,两组资料有可比性。 二、治疗方法 1.治疗组:用成都生物制品厂生产的乙肝免疫球
In view of the theory of persistent infection of hepatitis B virus and the low immune function of host, we injected hepatitis B immunoglobulin and hepatitis B vaccine into children with chronic hepatitis B virus from 1992 to 1993. At the same time, Oral administration of Oral treatment of children were controlled. Now the treatment effect of the two groups are reported below. Materials and Methods 1. Clinical data: All the patients in this group were outpatients, all of whom were treated for mild anorexia, fatigue and paleness. After laboratory examination, five markers of hepatitis B (ELISA), HBsAg, HBeAg, anti-HBc are positive, normal liver function, liver and spleen no significant enlargement. Select 400 cases were divided into two groups, 200 cases in each group, duration of 6 months to 8 years; age 3/2 to 14 years. Treatment group: 120 males and 80 females, 3/2 to 3 years in 61 cases, ~ 7 years in 80 cases, ~ 14 years in 59 cases. Control group: male 108 cases, female 92 cases, 3/2 to 3 years old 58 cases. ~ 7 years old 82 cases, ~ 14 years 60 cases. Two groups of age, hepatitis B five signs and clinical manifestations are similar, the two groups of data are comparable. Second, the treatment 1. Treatment group: Chengdu Biological Products Factory production of hepatitis B immunoglobulin