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目的:观察吲达帕胺治疗中枢性尿崩症的疗效并初步探讨其作用机制。方法:采用随机区组设计,对8例中枢性尿崩症患者轮流给予吲达帕胺25~75mg·d-1或卡马西平150~300mg·d-1或双氢氯噻嗪50~75mg·d-1口服治疗,连续8d,停药4d,依次更换药物二次,动态观察尿量及水盐代谢指标。结果:三药在用药的第4d,第8d尿量均较用药前为低;吲达帕胺在用药的第4d、第8d血钾、血氯较用药前降低,肾性活性较用药前升高(P<0.05)。结论:吲达帕胺对中枢性尿崩症有抗尿崩作用,电解质的改变和肾素血管紧张素醛固酮系统可能参与抗尿崩机制
Objective: To observe the efficacy of indapamide in treating central diabetes insipidus and to explore its mechanism. Methods: In a randomized block design, 8 patients with central diabetes insipidus were randomly assigned to receive indapamide 2.57.5 mg · d-1 or carbamazepine 150 ~ 300 mg · d-1 or hydrochlorothiazide 50 ~ 75mg · d-1 oral treatment, continuous 8d, withdrawal 4d, followed by changing the drug two times, dynamic observation of urine output and water and salt metabolism indicators. Results: The urine output of the three drugs on the 4th and 8th day were both lower than those before the drug treatment. The values of serum potassium and blood chlorine on the 4th and 8th day after administration of indapamide were lower than before treatment, High (P <0.05). CONCLUSION: Indapamide exerts anti-diabetic effect on central diabetes insipidus. Electrolyte alterations and renin-angiotensin-aldosterone system may be involved in anti-diabetes mechanism