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目的探讨葡萄糖－胰岛素－钾溶液（ＧＩＫ）对缺血脑组织的保护作用。方法采用ＺｅａＬｏｎｇａ方法制备脑缺血动物模型，ＧＩＫ组在大脑中动脉闭塞前３０ｍｉｎ给予胰岛素２Ｕ／ｋｇ腹部皮下注射，葡萄糖１０ｇ／ｋｇ、氯化钾０．２５ｇ／ｋｇ灌胃，术后２４ｈ，进行神经功能评分，取脑ＴＴＣ染色并测量梗塞体积，电镜观察梗塞灶边缘区超微结构，与对照组和假手术组对比分析。结果ＧＩＫ组死亡率低，神经功能评分高，脑梗塞体积小，与对照组比较有显著差异。超微结构显示神经元改变较轻。结论ＧＩＫ对缺血脑组织有保护作用。
Objective To investigate the protective effect of glucose-insulin-potassium solution (GIK) on ischemic brain tissue. Methods The animal models of cerebral ischemia were established by ZeaLonga method. The GIK group was injected subcutaneously with insulin (2U / kg), glucose 10g / kg and potassium chloride 0.25g / kg orally 30min before occlusion of the middle cerebral artery. The neurological function score, brain TTC staining and infarction volume were measured. Electrocardiography was used to observe the ultrastructure in the marginal zone of infarction. Compared with control group and sham operation group. Results In the GIK group, the mortality rate was low, the neurological function score was high, and the infarct size was small. There was a significant difference compared with the control group. Ultrastructural changes show less neuronal changes. Conclusion GIK has a protective effect on ischemic brain tissue.