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次氯酸(HCl O)是生物体内重要的活性氧(ROS)之一,在人类免疫功能系统中扮演着重要的角色,有助于对入侵细菌和病原体进行破坏.然而,过量的次氯酸或次氯酸盐会导致组织损伤和一系列疾病,如动脉硬化、关节炎和癌症等.因此,快速、灵敏、选择性检测生物样品中的HCl O相当重要.近年来,由于具备操作简单、检测限低、低毒性、高灵敏度和高选择性等多种优势,荧光探针方法检测次氯酸的研究得到了快速发展.按照不同的荧光基团综述了近几年HCl O荧光探针的设计、合成与应用进展.
Hypochlorous acid (HClO), one of the most important reactive oxygen species (ROS) in the body, plays an important role in the human immune system and helps to destroy invading bacteria and pathogens. However, excess hypochlorous acid Or hypochlorite can cause tissue damage and a range of diseases such as atherosclerosis, arthritis and cancer, etc. Therefore, it is very important to detect HClO in biological samples rapidly, sensitively and selectively.In recent years, due to its simple operation, Detection limit of low, low toxicity, high sensitivity and high selectivity and many other advantages, the fluorescent probe method for the detection of hypochlorous acid has been rapid development.According to different fluorophores are reviewed in recent years, HClO fluorescent probe Design, Synthesis and Application Progress.