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目的探讨短暂性脑缺血发作患者血清中神经元特异性烯醇化酶(NSE)的变化及临床意义。方法选择短暂性脑缺血发作患者52例,正常对照组30例,患者均于发病后48h内、5d时采集血清标本,采用酶联免疫法测定NSE水平。结果短暂性脑缺血发作组发病48h内NSE的水平显著高于对照组,P<0.01;短暂性脑缺血发作组发病48h内NSE的水平显著高于发病第5天NSE的水平,P>0.01。短暂性脑缺血发作组发病第5天NSE的水平与对照组比较,无统计学差异,P>0.05。结论短暂性脑缺血发作患者虽然脑的影像学检查未见异常,但神经元细胞存在一定程度上的损伤,损伤持续时间短,恢复快,动态测定NSE水平有助于短暂性脑缺血发作诊断的筛查。
Objective To investigate the changes of serum neuron specific enolase (NSE) in patients with transient ischemic attack and its clinical significance. Methods Fifty-two patients with transient ischemic attack and 30 normal controls were enrolled. Serum samples were collected within 48 hours and 5 days after the onset of illness, and the levels of NSE were determined by enzyme-linked immunosorbent assay. Results The level of NSE in the transient ischemic attack group was significantly higher than that in the control group within 48 hours after onset of onset (P <0.01). The level of NSE in the transient ischemic attack group was significantly higher than that in the fifth day after onset of transient ischemic attack (P> 0.01. Compared with the control group, the level of NSE on the 5th day after onset of transient ischemic attack group had no statistical difference (P> 0.05). Conclusions Although there is no abnormality in the imaging examination of the brain in patients with transient ischemic attack, the neuronal cells have a certain degree of damage, the duration of injury is short and the recovery is rapid. The dynamic determination of NSE level is helpful for transient ischemic attack Diagnostic screening.