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糖蛋白CD_5表达于所有成熟T 细胞和小部分B 淋巴细胞膜表面上。其在免疫上的确切作用尚不清楚。有报道指出CD_5在人和小鼠都可作为一个受体,以和CD_2,CD_(28)相类似的方式介导一个对T 细胞的共同刺激信号。抗CD_5抗体能刺激由CD_3结合TCR 介导的T 细胞增殖,并且也刺激IL-2分泌和其受体的表达,同时也诱导细胞内Ca~(++)浓度的增加。
Glycoprotein CD_5 is expressed on the surface of all mature T cells and a small fraction of B lymphocytes. Its exact role in immunization is unclear. It has been reported that CD_5 can be used as a receptor in both human and mouse to mediate a costimulatory signal to T cells in a manner similar to CD_2 and CD_ (28). Anti-CD5 antibodies can stimulate T cell-mediated T cell proliferation mediated by CD3 and also stimulate IL-2 secretion and its receptor expression as well as an increase in intracellular Ca ++ concentration.