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目的：观察睡必妥（Ｓｈｕｉｂｉｔｕｏ）吸入对小鼠中枢神经系统的作用及其吸入毒性和刺激性。方法：静式染毒柜小鼠吸入接触给药。ＹＳＤ－４Ｇ药理、生理实验多用仪测定实验小鼠自主活动，检测睡必妥与戊巴比妥钠的协同作用及对脑内５ＨＴ（５羟色胺），５ＨＩＡＡ（５羟吲哚乙酸）的影响。结果：睡必妥吸入能减少小鼠自主活动，与戊巴比妥钠具协同催眠作用，小鼠脑内５ＨＴ含量降低，５ＨＩＡＡ含量有增高趋势。睡必妥小鼠ＬＣ５０（２ｈ）大于７００００ｍｇ·ｍ－３，大鼠吸入接触睡必妥５９０００ｍｇ·ｍ－３４ｈ，连续３ｄ，对呼吸道粘膜组织无刺激性。结论：睡必妥具一定中枢抑制作用。其机制与苯二氮类安定药不同，可能与中枢神经递质５ＨＴ作用有关。睡必妥吸入毒性低，无刺激性
Objective: To observe the effects of inhalation of Shuibituo on the central nervous system of mice and its inhalation toxicity and irritation. Methods: mice were exposed to inhalation exposure. YSD-4G pharmacology, physiological experiments multi-instrument determination of spontaneous activity in mice, detection of sleep with a synergistic effect of pentobarbital and sodium 5 HT (5 serotonin), 5 HIAA (5-hydroxyindole D-Acetic acid). Results: Sleepless inhalation can reduce spontaneous activity in mice, and pentobarbital sodium with synergistic hypnotic effect in mice brain 5 HT content decreased, 5 HIAA content increased. The natriuretic mouse LC50 (2h) greater than 70000mg · m-3, inhalation of sleep in rats must sleep 59000mg · m-34h, continuous 3d, non-irritating to the respiratory mucosa. Conclusion: Sleeping must have a central inhibitory effect. Its mechanism and benzodiazepine diazepam different, may be related to the role of central neurotransmitter 5 HT. Sleep essential inhalation toxicity is low, non-irritating