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目的观察血府逐瘀汤联合西药治疗老年难治性高血压的临床疗效。方法将120例难治性高血压患者随机将分为对照组60例和试验组60例。对照组患者给予普萘洛尔片,每次5~10 mg,每日3~4次,口服;卡托普利片,每次12.5 mg,每日2~3次,口服;吲达帕胺片,每次2.5 mg,每日1次,口服。试验组在对照组的基础上增加中药汤剂血府逐瘀汤100 mL,每天1剂,早晚各服用半剂,口服。2组均治疗90 d。观察2组患者的临床症状和血压变化情况,评价2组患者的临床疗效。结果试验组总有效率为95.00%(57/60例),对照组为78.33%(47/60例),差异有统计学意义(P<0.05)。治疗后,对照组和试验组患者收缩压分别为(130.09±9.95),(113.08±15.24)mmHg,对照组和试验组患者舒张压分别为(84.40±9.05),(81.02±6.56)mmHg,差异有统计学意义(P<0.05)。试验组无药物不良反应发生,对照组发生头晕1例,2组患者的不良反应发生率差异无统计学意义(P>0.05)。结论血府逐瘀汤联合西药可有效治疗老年难治性高血压。
Objective To observe the clinical effect of Xuefu Zhuyu Decoction combined with Western medicine in the treatment of senile intractable hypertension. Methods A total of 120 patients with refractory hypertension were randomly divided into control group (60 cases) and experimental group (60 cases). Control group patients were given propranolol tablets, each 5 ~ 10 mg, 3 to 4 times a day orally; captopril tablets, each 12.5 mg, 2 to 3 times a day orally; indapamide Tablets, 2.5 mg each time, once daily, orally. The experimental group in the control group based on the increase of traditional Chinese medicine soup Xuefuzhuyu decoction 100 mL, day 1, morning and evening take each half a dose of oral. Both groups were treated for 90 days. Clinical symptoms and changes of blood pressure were observed in two groups of patients to evaluate the clinical efficacy of the two groups. Results The total effective rate was 95.00% (57/60) in the trial group and 78.33% (47/60) in the control group, the difference was statistically significant (P <0.05). After treatment, the systolic blood pressure in control group and experimental group were (130.09 ± 9.95) and (113.08 ± 15.24) mmHg, respectively. The diastolic blood pressure in control group and experimental group were (84.40 ± 9.05) and (81.02 ± 6.56) mmHg, There was statistical significance (P <0.05). There was no adverse drug reaction in the experimental group, 1 case of dizziness in the control group, and no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Xuefu Zhuyu Decoction combined with western medicine can effectively treat elderly refractory hypertension.