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【目的】评价持续性非卧床腹膜透析(CAPD)合并重度继发性甲状旁腺功能亢进症(SHPT)患者行阿法骨化醇胶囊(阿法迪三)冲击联合血液灌流(HP)治疗的疗效与安全性。【方法】收集本院 CAPD合并重度 SHPT患者37例。随机分为阿法迪三冲击联合 HP治疗组(A组,19例)和阿法迪三冲击治疗组(B组,18例)。两组药物起始剂量均为每次2~4μg,2次/周。A组同时血灌治疗,1次/周,共治疗3周。随访6月。比较两组治疗前后甲状旁腺激素(iPTH)值,临床症状及心脏瓣膜钙化情况。【结果】①治疗后,联合治疗组iPTH达标率、症状缓解率明显高于单独冲击组,且两组相比较差异有显著性(P<0.05)。②随访6个月, A组患者心脏瓣膜钙化率低于B组(73.6% vs 83.3%,P<0.05)。iPTH 达标率 A组高于 B组(94.7% vs 77.8%,P<0.05)。③A组治疗耐受性良好,无一例严重不良反应。B组中3例因高钙高磷血症中断阿法迪三治疗。【结论】合并重度 SHPT的CAPD患者,阿法迪三冲击联合 HP治疗较之单纯阿法迪三冲击具有更好的疗效及耐受性。“,”[Objective]To evaluate the efficacy and safety of alfacalcidol[1a-(OH)-D3 ]capsule pulse ther-apy combined with hemoperfusion(HP)for the treatment of continuous ambulatory peritoneal dialysis(CAPD) patients with severe secondary hyperparathyroidism(SHPT).[Methods]Totally 37 CAPD patients with severe SHPT were collected and randomly divided into alfacalcidol pulse therapy combined with HP treatment group (group A,n=19)and alfacalcidol pulse therapy group(group B,n=18).The drug initial dose of two groups was 2~4μg twice a week.Group A simultaneously received HP treatment once a week for 3 weeks.All pa-tients were followed up for 6 months.Immunoreactive parathyroid hormone(iPTH)level,clinical symptoms and cardiac valve calcification before and after treatment were compared.[Results]After treatment,the stand-ard reaching rate of iPTH and symptomatic relief rate in combination group were obviously higher than those in single pulse therapy group,and there was significant difference(P<0.05).After 6 month of follow up,car-diac valve calcification rate in group A was lower than that in group B(73.6% vs.83.3%,P<0.05),while the standard reaching rate of iPTH in group A was higher than that in group B(94.7% vs.77.8%,P <0.05).In group A,the tolerance was good and none had severe side reaction.In group B,3 patients discon-tinued alfacalcidol therapy due to hypercalcemia and hyperphosphatemia.[Conclusion]Alfacalcidol pulse ther-apy combined with HP for the treatment of CAPD patients with severe SHPT has better efficacy and tolerance than single alfacalcidol pulse therapy.