重症急性胰腺炎(Severe Acute Pancreatitis,SAP)是临床常见的急腹症,病死率高[1]。血液滤过可以清除过多的炎症介质,因此已用于全身感染的治疗,持续高容量血液滤过(HVHF)能降低血浆中炎性介质的水平[2]。近年来,血液灌流(HP)对于炎性因子的特异性吸附治疗也越来越受到关注,为进一步探讨持续HVHF和HP对于重症急性胰腺炎患者的有效性和安全性,我们观察了79例重症急性胰腺炎持续HVHF治疗和间断HP治 Severe acute pancreatitis (Severe Acute Pancreatitis, SAP) is a common clinical acute abdomen, high mortality [1]. Hemofiltration can remove excess inflammatory mediators and has therefore been used for the treatment of systemic infections. Continuous high volume hemofiltration (HVHF) can reduce the level of inflammatory mediators in plasma [2]. In recent years, hemoperfusion (HP) for the specific absorption of inflammatory cytokines is also more and more attention, in order to further investigate the sustained HVHF and HP in patients with severe acute pancreatitis, efficacy and safety, we observed 79 cases of severe disease Acute pancreatitis persistent HVHF treatment and intermittent HP treatment