Today’s emergence of nano-micro hybrid structures with almost biological complexity is of fundamental interest.Our ability to adapt intelligently to the challenges has rami?cations all the way from fundamentally changing research itself,over applications critical to future survival,to posing globally existential dangers.Touching on speci?c issues such as how complexity relates to the catalytic prowess of multi-metal compounds,we discuss the increasingly urgent issues in nanotechnology also very generally and guided by the motto‘Bio Is Nature’s Nanotech’.Technology belongs to macro-evolution;for example integration with arti?cial intelligence(AI)is inevitable.Darwinian adaptation manifests as integration of complexity,and awareness of this helps in developing adaptable research methods that can?nd use across a wide range of research.The second half of this work reviews a diverse range of projects which all bene?ted from‘playful’programming aimed at dealing with complexity.The main purpose of reviewing them is to show how such projects bene?t from and?t in with the general,philosophical approach,proving the relevance of the‘big picture’where it is usually disregarded. Today’s emergence of nano-micro hybrid structures with almost biological complexity is of fundamental interest. Our ability to adapt intelligently to the challenges has rami? Cations all the way from fundamentally changing research itself, over applications critical to future survival, to posing global existential dangers Touching on speci? C issues such as how complexity involves the catalytic prowess of multi-metal compounds, we discuss the increasingly urgent issues in nanotechnology also very generally and guided by the motto ’Bio Is Nature’s Nanotech. "Technology belongs to macro- evolution; for example integration with arti? cial intelligence (AI) is inevitable. Darwinian adaptation manifests as integration of complexity, and awareness of this help in developing adaptable research methods that can? nd use across a wide range of research. second half of this work reviews a diverse range of projects which all bene? ted from’playful’programming aimed at dealing with complexity.Th e main purpose of reviewing them is to show how such projects bene? t from and? t in with the general, philosophical approach, proving the relevance of the ’picture’ where it is usually disregarded.