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目的探讨通心络与阿司匹林联合或替代治疗对血小板聚集率的影响。方法选取接受阿司匹林治疗的患者302例。根据血小板聚集率筛选阿司匹林抵抗患者。按时间顺序入组,以洗脱方式分组。停用阿司匹林2周,服通心络8粒+阿司匹林100mg/d,1个月,再停药2周,服通心络8粒/d,1个月。复查血小板聚集率。结果302例患者中58例存在阿司匹林抵抗,占19.2%。通心络+阿司匹林组与通心络组服药后1个月血小板聚集率均明显下降(均为P<0.05)。结论通心络可以降低血小板聚集率,对于阿司匹林抵抗患者,选用通心络治疗可以取得一定的疗效。
Objective To investigate the effect of Tongxinluo combined with aspirin on platelet aggregation rate. Methods 302 patients who received aspirin were selected. According to platelet aggregation rate screening aspirin resistance patients. Chronologically into the group, the elution method grouping. Aspirin was discontinued for 2 weeks, serving 8 tablets of Xinluo and 100mg / d of aspirin for 1 month, and then stopped for 2 weeks. Review platelet aggregation rate. Results In 302 patients, 58 patients had aspirin resistance, accounting for 19.2%. Tongxinluo + Tongxinluo group and Tongxinluo group had a significant decrease of platelet aggregation at 1 month (both P <0.05). Conclusion Tongxinluo can reduce the rate of platelet aggregation, aspirin resistance patients, the choice of Tongxinluo treatment can achieve some effect.