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用 HRP追踪法与免疫细胞化学法观察了大鼠直肠内 P物质 (SP)、降钙素基因相关肽 (CGRP)和血管活性肠肽(VIP)三种肽能神经的支配与来源。结果显示 :1直肠 CGRP和 VIP肽能神经起源于盆丛副交感神经节 (PSG)。 2直肠感觉神经纤维来自骶 2～ 4节段双侧背根神经节 (S2 - 4 - DRG) SP能或 CGRP能神经元。 3感觉神经元的中枢突进入骶髓 2 -3节段后角并形成较粗大的外侧束 ,其中大部分传入纤维经后角外侧缘走行 ,终止于侧角区中间外侧核交感神经元胞体周围。其余部分传入纤维延伸到骶髓 2 - 3节段灰质第 、 层和灰质后连合核 (中央自主神经核 ) ,进入中间外侧核的传入纤维与后连合核也有联系。上述结果提示 ,支配直肠的 VIP能神经元参与了直肠肌运动的调节 ;SP和 CGRP能神经元可能与直肠的运动、感觉调节有关。
The innervation and origin of three kinds of peptidergic nerves in the rectum, including substance P (SP), calcitonin gene related peptide (CGRP) and vasoactive intestinal peptide (VIP), were observed by HRP tracing and immunocytochemistry. The results showed that: 1 Rectal CGRP and VIP peptide nerve originated from the pelvic parasympathetic ganglia (PSG). 2 The sensory nerve fibers of the rectum come from the spinal dorsal root ganglion (S2 - 4 - DRG) SP or CGRP neurons in sacral segments 2 ~ 4. 3 sensory neurons protrude into the posterior horn of the 2-segment segment of the sacral canal and form a thicker lateral bundle, most of which pass through the lateral margin of the posterior horn and terminate in the medial lateral nucleus of sympathetic neurons around. The remaining part of the afferent fibers extend to the commissural nucleus (central autonomic nucleus) in the sacrococcygeal 2 - 3 segmental gray matter, layers and gray matter. The afferent fibers entering the medial lateral nucleus are also associated with the posterior commissural nucleus. The above results suggest that VIP-competent neurons that dominate the rectum are involved in the regulation of rectal muscle motility. SP and CGRP-capable neurons may be involved in motor and sensory regulation of the rectum.