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为研究递增运动负荷对大鼠下丘脑-垂体-肾上腺轴(HPA)与下丘脑-垂体-甲状腺轴(HPT)激素的影响,进一步探讨运动性月经失调(AMI)和HPA、HPT轴激素变化的关系。将成熟、健康的两月龄雌性SD大鼠35只随机分为5组进行研究,结果发现:1)随着运动负荷递增,ACTH、PRL、TRH、TSH的水平逐渐升高,Ta组大鼠阴道中底层细胞数量逐周增加,第七周最高;2)Ta组血ACTH、PRL与C组相比,存在显著性差异(P<0.05);Ta组血TSH和C组相比,存在显著性差异(P<0.01);Tb组血TRH和C组相比,存在显著性差异(P<0.01)。恢复一周后,ACTH、TRH的水平均有所下降。3)经过7周的递增负荷训练,Ta组大鼠肾上腺重量明显高于C组(P<0.01),休息一周后略有恢复,但仍高于C组(P<0.05);Ta组大鼠甲状腺重量明显低于C组(P<0.01)。结论:1)长期大强度运动导致HPA轴高度活化,肾上腺功能亢进,诱导AMI发生。2)长期大强度运动导致HPT轴功能紊乱,甲状腺功能减退,诱导AMI发生。3)提示:AMI是多器官多系统交互作用的结果,HPA轴高度活化、HPT轴功能紊乱及PRL水平升高均可导致AMI的发生。
To investigate the effect of increasing exercise load on the hypothalamus-pituitary-adrenal axis (HPA) and hypothalamus-pituitary-thyroid axis (HPT) hormones in rats, and to explore the relationship between exercise-induced menstrual disorders (AMI) and HPA and HPT axis hormones relationship. Thirty-five mature and healthy two-month-old female Sprague-Dawley rats were randomly divided into five groups. The results showed that: 1) As the exercise load increased, the levels of ACTH, PRL, TRH and TSH gradually increased, The number of basal cells in the vagina increased week by week, and the highest in the seventh week. (2) Compared with the C group, there were significant differences in ACTH and PRL between the Ta group and the C group (P <0.05) (P <0.01). There was a significant difference between TR group and C group (P <0.01). Recovery a week later, ACTH, TRH levels have declined. 3) After 7 weeks of incremental load training, the adrenal weight of Ta group was significantly higher than that of C group (P <0.01), and recovered slightly after one week rest, but still higher than that of C group (P <0.05) Thyroid weight was significantly lower than the C group (P <0.01). Conclusion: 1) Long-term high-intensity exercise results in highly activated HPA axis, hyperenalidation and induction of AMI. 2) Long-term high-intensity exercise led to HPT axis dysfunction, hypothyroidism, induction of AMI. 3) Hint: AMI is the result of multi-organ system interaction. High HPA axis activation, HPT axis dysfunction and elevated PRL level may lead to AMI.