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目的 建立细菌性脑膜炎模型 ,探讨本病的发病机制、治疗和并发症防治。方法 通过对 3周龄SD大鼠脑池内注射肺炎链球菌 ,观察脑脊液和脑的病理改变。结果 接种后 2 4hSD大鼠出现精神稍差 ,进食少 ,嗜睡 ,反应差 ,重者反应迟钝、运动失调 ,偶有偏瘫 ,四肢发绀 ,体温不升 ,最终昏迷伴全身抽搐。脑脊液白细胞数明显增高 ,脑实质有点状出血 ,蛛网膜下腔、脑室和软脑膜有炎症渗出 ,皮质和海马齿状回、CA1区神经元受损。结论 脑池内直接注射细菌后 ,能在一定时程内诱导出细菌性脑膜炎
Objective To establish a bacterial meningitis model to explore the pathogenesis of the disease, treatment and prevention of complications. Methods Pathological changes of cerebrospinal fluid and brain were observed by injecting S. pneumoniae into the cistern of 3-week-old SD rats. Results After inoculation, 24 h SD rats appeared slightly less mental, less eating, drowsiness, poor response, severe unresponsiveness, dyskinesia, occasional hemiplegia, limbs and cyanosis, body temperature does not rise, the final coma with generalized convulsions. Cerebrospinal fluid leukocyte increased significantly, a little bit of brain parenchymal hemorrhage, subarachnoid, ventricular and pia mater inflammatory exudation, cortical and hippocampal dentate gyrus, CA1 neurons damaged. Conclusion Bacterial meningitis can be induced within a certain time course after direct injection of bacteria in the brain pool