论文部分内容阅读
目的目前,内蒙古地区仍然缺乏三阴性乳腺癌临床及病理特征的研究资料,本项研究旨在阐明内蒙古中部地区妇女三阴性乳腺癌相关危险因素及临床病理学特征。方法我们对210例于2009年5月至2013年10月收集的乳腺癌患者的临床资料进行分析,其中三阴性乳腺癌组90人,非三阴性乳腺癌组120人,比较两组之间的年龄、生活习惯、种族、居住地区、生殖因素以及临床病理学特征。结果三阴性乳腺癌发病率在年龄<60岁(OR=2.783,95%CI 1.380~5.001)、BMI>25 kg/m2(OR=3.804,95%CI 1.668~4.287)、抑制泌乳(OR=2.306,95%CI 1.426~5.048)、使用避孕药(OR=1.832,95%CI 1.046~3.656)、产次>2次的患者(OR=1.256,95%CI 1.321~4.347)、绝经前妇女(OR=1.631,95%CI 1.324-3.474)、牧区居民(OR=1.186,95%CI 0.463~2.165)、蒙古族(OR=1.58,95%CI:1.49~2.28)以及嗜酒(OR=1.276,95%CI 0.372~2.148)中高于对照组。三阴性乳腺癌主要为进展期的浸润性导管癌,并且具有更高的T和M分期。结论我们的研究表明年龄、肥胖、抑制泌乳以及使用口服避孕药等因素均为内蒙古地区妇女三阴性乳腺癌的危险因素。此外与非三阴性乳腺癌相比,三阴性乳腺癌远处转移早,恶性程度高,临床预后差。
Objective Currently, there is still a lack of data on the clinical and pathological features of triple negative breast cancer in Inner Mongolia. This study aimed to elucidate the risk factors and clinicopathological features of triple negative breast cancer in central Inner Mongolia. Methods We analyzed the clinical data of 210 breast cancer patients collected from May 2009 to October 2013, of which 90 were in triple negative breast cancer group and 120 in non-triple negative breast cancer group. The differences between the two groups Age, lifestyle, race, place of residence, reproductive factors, and clinicopathological features. Results The incidence of triple-negative breast cancer was significantly lower than that of patients younger than 60 years old (OR = 2.783, 95% CI 1.380-5.001) and BMI> 25 kg / m2 (OR = 3.804, 95% CI 1.668-4.287) (OR = 1.256, 95% CI 1.321 ~ 4.347), premenopausal women (OR = 1.256, 95% CI 1.426-5.048, OR = 1.832,95% CI 1.046-3.656) (OR = 1.186, 95% CI 0.463 ~ 2.165), Mongolian (OR = 1.58, 95% CI: 1.49-2.28) and alcohol consumption (OR = 1.276, 95% CI = 1.324-3.474) % CI 0.372 ~ 2.148) higher than the control group. Triple negative breast cancer is primarily a progressive invasive ductal carcinoma with a higher T and M staging. Conclusions Our study shows that age, obesity, lactation suppression and the use of oral contraceptives and other factors are all risk factors for triple negative breast cancer in Inner Mongolia. In addition, compared with non-triple negative breast cancer, triple negative breast cancer distant metastasis of early, high degree of malignancy, poor clinical prognosis.