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为评估高频震荡通气 (HFOV)对新生儿重度呼吸衰竭氧合功能及预后的影响 ,对18例常频辅助通气(CMV)和药物治疗失败的呼吸衰竭患儿 ,采用HFOV(美国产Sensormedics3100A)治疗 ,并进行肺部氧合功能和预后评价。结果表明 ,用HFOV3h后 ,18例患儿动脉血氧分压与吸入氧浓度比和动脉肺泡氧压比 (87.5±10.8,0.16±0.08)较使用前 (52.6±5.40,0.08±0.02)明显升高 (P<0.05) ;治疗前氧合指数 (30±10) ,治疗3h后明显下降 (16±10) ,差异有显著性 (P<0.05) ;至9h所有指标较治疗前差异有极显著性 (P均<0.01) ;18例患儿中存活15例 (83.3 % ) ,胎粪吸入综合征 (7/7例 )和肺间质气肿并气漏 (5/5例 )的患儿存活率最高。提示重症呼吸衰竭患儿CMV失败者 ,改用HFOV能有效改善氧合 ,降低给氧浓度
To assess the effect of high frequency oscillatory ventilation (HFOV) on the oxygenation function and prognosis of severe respiratory failure in neonates, HFOV (American-made Sensormedics3100A) was used in 18 children with respiratory failure who had frequent auxiliary ventilation (CMV) and drug failure. Treatment, and lung oxygenation function and prognosis. The results showed that with HFOV3h, the ratio of arterial partial pressure of oxygen to inhaled oxygen and the ratio of pulmonary arterial pressure of oxygen (87.5 ± 10.8,0.16 ± 0.08) were significantly increased in 18 cases (52.6 ± 5.40,0.08 ± 0.02) (P <0.05). Before the treatment, the oxygenation index (30 ± 10) decreased obviously after 3h treatment (16 ± 10), the difference was significant (P <0.05) (P <0.01). There were 15 children (83.3%) surviving in 18 cases, 7/7 cases of meconium aspiration syndrome and 5/5 cases of interstitial emphysema and air leak The highest survival rate. Prompt CMV failure in children with severe respiratory failure, switch to HFOV can effectively improve oxygenation, reduce oxygen concentration