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目的探讨硒对阿霉素肾毒性的防护作用及作用机理。方法采用紫外分光光度法、邻苯三酚自氧化法等方法测定不同剂量、不同顺序补硒后大鼠血中过氧化氢酶（ＣＡＴ）、超氧化物歧化酶（ＳＯＤ）、谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性及过氧化脂质（ＬＰＯ）含量的变化。结果补充硒（Ｓｅ）制剂可显著提高应用阿霉素后大鼠血液中ＣＡＴ、ＳＯＤ、ＧＳＨ－Ｐｘ活性，尤以ＧＳＨ－Ｐｘ为著，Ｌｐｏ生成明显下降；预防性应用和及时补Ｓｅ，可有效阻抗阿霉素产生的毒性作用；一旦大鼠阿霉素肾病形成再行补Ｓｅ，则呈现不可逆变化（短期内）。结论硒对阿霉素产生的肾毒性具有防护作用
Objective To investigate the protective effect and mechanism of selenium on adriamycin-induced nephrotoxicity. METHODS: Catalase (CAT), superoxide dismutase (SOD), and glutathione in blood of rats after selenium supplementation with different doses and different orders were determined by ultraviolet spectrophotometry and pyrogallol autoxidation method. Changes in peroxidase (GSH-Px) activity and lipid peroxidation (LPO) content. Results Supplementation of selenium (Se) could significantly increase the activity of CAT, SOD, and GSH-Px in rat blood after administration of adriamycin, especially GSH-Px, and the production of Lpo was significantly decreased. Prophylactic application and timely supplementation of se The toxic effects of effective doxorubicin dosing; irreversible changes (in the short-term) occur when the rat adriamycin nephropathy is supplemented with selenium supplementation. Conclusion Selenium has protective effect on renal toxicity induced by adriamycin