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目的 :探析支原体肺炎患儿感染后的免疫功能变化的临床价值。方法 :分析2014年10月~2016年10月在我院接受治疗的72例支原体肺炎感染患儿(观察组)的临床资料。另外选取同期在我院接受健康体检的72例健康儿童作为此次研究的对照组。比较两组儿童的一般资料、补体及免疫球蛋白水平、红细胞免疫水平及外周血T淋巴细胞亚群。结果 :两组患儿的一般资料无显著差异性。观察组患儿的血清Ig A、Ig M、Ig G及补体C3、C4的表达水平均显著较对照组低,且急性期变化幅度较恢复期大。观察组患儿的免疫复合物花环率、C3b受体花环率及免疫黏附促进因子均显著较对照组低,而免疫黏附抑制因子则显著较对照组高,且急性期变化幅度较恢复期大。观察组患儿的CD3+、CD4+及CD4+/CD8+均显著较对照组低,而CD8+则明显较对照组高,且急性期变化幅度较恢复期大。结论 :支原体肺炎感染患儿的免疫功能相对处于低下状态,且对其免疫状态的调节可以有效改善患儿的疾病状态,值得推广。
Objective: To investigate the clinical value of immune function changes in children with Mycoplasma pneumoniae infection. Methods: The clinical data of 72 patients with mycoplasma pneumoniae infection (observation group) who were treated in our hospital from October 2014 to October 2016 were analyzed. In addition, we selected 72 healthy children who were in our hospital during the same period as the control group in this study. General data, complement and immunoglobulin levels, erythrocyte immunity and peripheral T lymphocyte subsets were compared between the two groups. Results: There was no significant difference in general data between the two groups. The serum levels of Ig A, Ig M, Ig G and C3 and C4 of the observation group were significantly lower than those of the control group, and the changes in the acute phase were more than those in the recovery phase. The rosette rate, C3b receptor rosette rate and immunoadsorption promoting factor of immune complex in observation group were significantly lower than those in control group, while the immunoadhesion inhibition factor was significantly higher than that in control group, and the change range of acute phase was larger than that of recovery group. The CD3 +, CD4 + and CD4 + / CD8 + in the observation group were significantly lower than those in the control group, while the expression of CD8 + in the observation group was significantly higher than that in the control group. Conclusion: The immune function of children with mycoplasma pneumonia infection is relatively low, and its immune status can effectively improve the disease status of children, which is worth promoting.