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目的了解结直肠腺瘤性息肉患者的血浆同型半胱氨酸和血清叶酸水平,并探讨之间的关系。方法选取42例结直肠腺瘤性息肉患者和46例健康对照者,测定其血浆同型半胱氨酸水平及血清叶酸水平。结果结直肠腺瘤性息肉患者的血浆同型半胱氨酸水平显著高于健康对照者(15.04μmol/L±4.80μmol/Lvs8.23μmol/L±3.70μmol/L,P<0.001),血清叶酸水平显著低于健康对照者(4.46 ng/mL±3.63 ng/mLvs13.65 ng/mL±4.86 ng/mL,P<0.001)。结论结直肠腺瘤性息肉与血浆同型半胱氨酸水平升高和血清叶酸水平降低之间存在一定联系,可能是结直肠腺瘤性息肉的危险因素,有必要对此作进一步的探讨。
Objective To understand the plasma homocysteine and serum folic acid levels in patients with colorectal adenomatous polyps and to explore the relationship between them. Methods 42 patients with colorectal adenomatous polyps and 46 healthy controls were selected for determination of plasma homocysteine and serum folic acid levels. Results The level of plasma homocysteine in patients with colorectal adenomatous polyps was significantly higher than that in healthy controls (15.04μmol / L ± 4.80μmol / L vs 8.23μmol / L ± 3.70μmol / L, P <0.001) Significantly lower than the healthy controls (4.46 ng / mL ± 3.63 ng / mL vs 13.65 ng / mL ± 4.86 ng / mL, P <0.001). Conclusion The relationship between colorectal adenomatous polyps and plasma homocysteine levels and serum folate levels may be a risk factor for colorectal adenomatous polyps. It is necessary to further investigate this.