Huperzine A ameliorates obesity-related cognitive performance impairments involving neuronal insulin

来源 :中国药理学报(英文版) | 被引量 : 0次 | 上传用户:a447047964
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Type 2 diabetes (T2D) and Alzheimer’s disease (AD) share several common pathophysiological features.Huperzine A (Hup A),a Lycopodium alkaloid extracted from the Chinese herb moss Huperzia serrata,is a specific and reversible inhibitor of acetylcholinesterase,which is clinically used for the treatment of AD.In this study,we investigated whether Hup A improved the metabolic and cognitive functions in the high fat-induced (HFD) obese mice and genetic ob/ob mice.HFD and ob/ob mice were treated with Hup A (0.1,0.3 mg· kg-1· d-1,ig) for 3 months.Body weight was monitored and glucose tolerance tests were performed.Novel object recognition test and Morris water maze assay were conducted to evaluate the cognitive functions.We found that the Hup A treatment had no significant effect on peripheral metabolism of obese mice,whereas Hup A (0.1,mg· kg-1· d-1) improved both the abilities of object recognition and spatial memory in HFD-fed mice,but not in ob/ob mice.Furthermore,Hup A treatment significantly upregulated the insulin and phosphorylated Akt levels in the cortex of HFD-fed mice,but not ob/ob mice.In addition,Hup A (0.3,mg· kg-1· d-1) significantly decreased cortical β-secretase (BACE1) expression.In conclusion,these results demonstrate that treatment with Hup A (0.1,mg· kg-1· d-1) can effectively improve the cognitive functions,at least in diet-induced obese mice.
其他文献
生机勃勃的舆论监督,颇有力度的批评性报道。这是我参加第七届全国优秀广播节目评选以后留下的一个印象。批评性报道,是舆论监督的一种主要的、直接的形式。同往年比较,1988
Lung cancer is one of the most common human cancers and the number one cancer killer in the United States. In general, lung cancer includes small cell lung canc
Since first described in 1982.intraductal papillary mucinous neoplasm(IPMN)has been the preferred term to describe the proliferation of the pancreatic ductal ep
Birth-to-death,with disease shares the contours.That is everyone’s destiny.rnBut in health we care,we struggle for healthier life,better medicine,and dignifie
From the limited but available information,we traced the history of developments of liver surgery and transplantation in China.Liver surgery first started in th
Translational medicine has newly emerged to bridge the gap between bench-related basic science research and bedside clinical practice. From early diagnosis to l
Hypertension is characterized by vascular smooth muscle constriction and vascular remodeling involving cell migration, hypertrophy and growth. Crk-associated su
In order to provide a sensitive cell line model for investigating the mechanisms underlying the lymphatic metastasis of tumors and the effect of medicine agains
A lot of progress has been made on inteal medicine in the past year.Here a great deal of data were collected about inteal medicine in China by searching for som
Midbrain dopaminergic (DA) neurons are goveed by an endogenous cholinergic system,originated in the mesopontine nuclei.Nicotine hijacks nicotinic acetylcholine