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用17-FE细胞化学法测定41例女性乳腺癌患者雌激素受体(ER),并观察其与肿瘤细胞对5-FU敏感性的关系。30例作短期化疗后,平均ER阳性细胞率从12.4％升至18.6％(P<0.02),化疗前ER阴性者上升更明显,提示ER阴性者肿瘤细胞分化差,对5-FU更敏感;11例作原代细胞培养及药物敏感试验,高敏组ER阳性细胞率低而核仁ER阳性率高,提示ER状态在一定程度上可预测肿瘤细胞对化疗药物的敏感性。
The 17 estrogen receptor (ER) in 41 cases of female breast cancer patients were determined by 17-FE cytochemistry. The relationship between estrogen receptor (ER) and 5-FU sensitivity of tumor cells was observed. The average ER positive rate increased from 12.4% to 18.6% (P <0.02) after 30 cases of short-term chemotherapy. ER-positive patients increased more obviously before chemotherapy, which indicated that ER-negative cells were poorly differentiated and more sensitive to 5-FU. 11 cases of primary cell culture and drug sensitivity test, high-sensitive group of ER-positive cells and low ER nucleus ER positive rate, suggesting that ER status to a certain extent, the sensitivity of tumor cells to chemotherapeutic drugs.