随着对肿瘤发病机制的逐步深入研究,人们认识到表观遗传学这些DNA序列以外的调控机制异常在肿瘤的发生、发展过程中起了重要作用。DNA甲基化、micro RNA表达调控及组蛋白的修饰等表观遗传机制是宫颈癌发生、发展的重要原因之一。表观遗传学的研究进展不仅有助于宫颈癌的早期诊断,对于分子靶向治疗宫颈癌亦具有良好的应用前景。 With the gradual and deeper study on the pathogenesis of cancer, it is recognized that abnormalities of the regulatory mechanisms other than epigenetics outside these DNA sequences play an important role in the occurrence and development of tumors. Epigenetic mechanisms such as DNA methylation, regulation of micro RNA expression and histone modification are one of the important reasons for the occurrence and development of cervical cancer. Epigenetic research advances not only contribute to the early diagnosis of cervical cancer, molecular targeted therapy for cervical cancer also has a good prospect.