论文部分内容阅读
目的探讨鼻咽癌(NPC)survivin、Bcl-2及nm23-H1的表达与18F-FDGPET标准化摄取值(SUV)的关系。方法 32例经病理组织学确诊的初治NPC患者于治疗前均行全身18F-脱氧葡萄糖PET显像,测定平均SUV值,鼻咽活检病理标本经常规石蜡切片,用免疫组织化学技术检测肿瘤组织survivin、Bcl-2及nm23-H1的表达,计算survivin、Bcl-2及nm23-H1阳性表达百分数。结果 (1)NPC中survivin阳性表达率为69%(22/32),Survivin阳性患者平均SUV值与阴性患者比较差异无统计学意义(7.68±1.64vs6.87±1.01,P>0.05);(2)NPC中Bcl-2阳性表达率为72%(23/32),Bcl-2阳性患者平均SUV值与阴性患者比较差异无统计学意义(7.21±1.45vs7.16±2.55,P>0.05);(3)NPC中nm23-H1阳性表达率为56%(18/32),nm23-H1阳性患者平均SUV值较阴性患者明显降低(5.90±1.06vs8.07±1.43),差异有统计学意义(P<0.01)。结论 NPC中存在survivin、Bcl-2、nm23-H1高表达;Survivin、Bcl-2阳性表达与SUV值无相关性,nm23-H1阳性表达与SUV值具有相关性。
Objective To investigate the relationship between the expression of survivin, Bcl-2 and nm23-H1 in nasopharyngeal carcinoma (NPC) and the normalized 18F-FDG PETET (SUV). Methods Thirty-two patients with newly diagnosed NPC diagnosed by histopathology were treated with whole-body 18F-deoxyglucose PET imaging before treatment. The mean SUV was measured. The paraffin sections were obtained by routine biopsy of nasopharyngeal biopsies. The tumor tissues were detected by immunohistochemistry Survivin, Bcl-2 and nm23-H1 were detected and the percentages of survivin, Bcl-2 and nm23-H1 were calculated. Results (1) The positive rate of survivin expression in NPC was 69% (22/32). There was no significant difference between the average survivin positive patients and the negative patients (7.68 ± 1.64 vs 6.87 ± 1.01, P> 0.05) 2) The positive expression rate of Bcl-2 in NPC was 72% (23/32). There was no significant difference in mean SUV between Bcl-2 positive patients and negative patients (7.21 ± 1.45vs7.16 ± 2.55, P> 0.05) ; (3) The positive expression rate of nm23-H1 in NPC was 56% (18/32), the mean SUV of patients with nm23-H1 positive was significantly lower than that of negative patients (5.90 ± 1.06 vs 8.07 ± 1.43), the difference was statistically significant (P <0.01). Conclusions There is a high expression of survivin, Bcl-2 and nm23-H1 in NPC. The expression of Survivin and Bcl-2 has no correlation with SUV. The correlation between the expression of nm23-H1 and SUV was significant.