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目的 观察老年冠心病合并非胰岛素依赖型糖尿病(NIDDM)患者血栓前状态分子标志物的变化及意义。方法 对观察组60例患者(稳定型心绞痛18例、不稳定型心绞痛19例、不稳定型心绞痛合并NIDDM 23例)和对照组18例正常人体内血栓前状态分子标志物、血管内皮功能以及脂质过氧化物水平进行检测,并回归分析其之间的相关性。结果 老年冠心病合并NIDDM患者存在明显的血栓前状态分子标志物变化,并且这种变化与内皮功能失调以及脂质过氧化损伤密切相关。结论 老年冠心病合并NIDDM患者存在明显的血栓前状态分子标志物变化,可能与血管内皮功能障碍及脂质过氧化损伤有关。
Objective To observe the changes and clinical significance of prethrombotic state molecular markers in elderly patients with coronary heart disease and non-insulin dependent diabetes mellitus (NIDDM). Methods Sixty patients (18 cases of stable angina pectoris, 19 cases of unstable angina pectoris, 23 cases of unstable angina pectoris with NIDDM) and 18 cases of normal control group were enrolled in the study. Their prethrombotic state molecular markers, vascular endothelial function and lipid Peroxides levels were tested and their correlations were analyzed by regression analysis. Results There were obvious changes of molecular markers of prethrombosis in elderly patients with coronary heart disease and NIDDM, and this change was closely related to endothelial dysfunction and lipid peroxidation injury. Conclusion There are obvious changes of molecular markers of prethrombotic state in elderly patients with coronary heart disease and NIDDM, which may be related to vascular endothelial dysfunction and lipid peroxidation injury.