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目的评价交联糊精微球可否作为吸收伤口渗出物的给药载体。方法用反相悬浮交联法制备微球,考察乳化及交联过程中单因素的影响,确定反应条件;通过红外光谱分析、激光衍射粒度分析、差示扫描量热分析、热重分析等手段研究微球的结构及外观;通过对比的方法考察乙醇的体积分数、NaC l的质量浓度、pH值对微球吸水度的影响。结果油水质量比为34.4∶40.0、乳化剂用量为10 g、搅拌速度为600 r.min-1、乳化30 min后,加入交联剂,65℃下交联2.0 h可以获得100μm左右、粒径分布窄、形状圆整的微球;红外光谱和热分析证明,糊精在交联后结构和性质发生很大变化,大量羟基的存在使产物仍具有强亲水性,交联后生成的三维网状结构使其吸水后可以溶胀并保持一定的形态;交联糊精微球的吸水度随着乙醇体积分数的增加而显著降低,NaC l质量浓度在4~18 g.L-1内、pH值在1~13内吸水度变化不大。结论制备的交联糊精微球可以作为给药载体,用于有渗出物伤口的治疗。
Objective To evaluate whether the crosslinked dextrin microspheres can be used as drug delivery carrier to absorb wound exudate. Methods The microspheres were prepared by reversed-phase suspension cross-linking method. The influence of single factor during emulsification and cross-linking process was investigated. The reaction conditions were determined. By means of infrared spectroscopy, laser diffraction particle size analysis, differential scanning calorimetry and thermogravimetric analysis The microstructure and appearance of the microspheres were investigated. The volume fraction of ethanol, the mass concentration of NaC 1 and the pH value on the microspheres’ water absorption were investigated. The results showed that the mass ratio of oil to water was 34.4:40.0, the dosage of emulsifier was 10 g, the stirring speed was 600 r.min-1. After emulsified for 30 min, the cross-linking agent was added at 65 ℃ for 2.0 h, Distribution and shape of the microspheres are narrow. The results of FTIR and thermal analysis show that the structure and properties of the dextrin undergo a great change after the crosslinking. The presence of a large amount of hydroxyl groups makes the product still have strong hydrophilicity. The three-dimensional The network structure can make it swell and maintain a certain shape after absorbing water. The water absorption of the crosslinked dextrin microspheres decreased significantly with the increase of the volume fraction of ethanol. The mass concentration of NaC l was in the range of 4 ~ 18 gL-1, 1 ~ 13 little change in water absorption. Conclusions The prepared crosslinked dextrin microspheres can be used as drug carrier for the treatment of exudate wounds.