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研究表明，ｎｍ２３基因的表达与多种实验性肿瘤［１，２］及人类恶性肿瘤［３－５］的转移潜能密切负相关，提示它是一种能抑制肿瘤转移表型的转移抑制基因．ｐ５３在多种肿瘤中均有过度表达，并与肿瘤分化、转移和预后有关．我们应用免疫组织化学方法检测了大肠癌中ｎｍ２３
Studies have shown that nm23 gene expression is closely related to the metastatic potential of various experimental tumors [1,2] and human malignant tumors [3-5], suggesting that it is a metastasis suppressor gene that can inhibit the metastasis phenotype. P53 is overexpressed in a variety of tumors and is associated with tumor differentiation, metastasis, and prognosis. We used immunohistochemistry to detect nm23 in colorectal cancer