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本文采用图像定量分析和形态测量方法,对缺氧及服用中草药异叶青兰的大鼠海马CA3区超微结构进行形态定量观察.结果表明,缺氧组海马锥体细胞肿胀;粗面内质网脱颗粒、网池扩张、断裂,并且失去正常的绕核或平行成层的分布形式;线粒体明显肿胀、嵴断裂,数量减少,平均截面积增大;髓鞘变性,轴突和树突内线粒体肿胀明显;轴棘、轴树突触间隙宽度变窄.缺氧给药组海马锥体细胞无明显肿胀;线粒体数量增多,平均截面积无明显增大,线粒体嵴结构完整.本文对各组形态变化的差异进行了探讨.
In this study, image quantitative analysis and morphometric methods were used to quantitatively observe the ultrastructure of hippocampal CA3 region in rats exposed to hypoxia and Chinese herbal medicine C. variegata. The results showed that hippocampal pyramidal cells in the hypoxic group were swollen; rough endoplasmic reticulum was removed. Particles, cistern expansion, fracture, and loss of normal distribution around the nucleus or parallel stratification; mitochondria significantly swollen, tendon rupture, reduced in number, average cross-sectional area increased; myelin sheath degeneration, mitochondria swelling in axons and dendrites Obviously, the width of the synaptic cleft between the spines and the axons was narrowed. There was no obvious swelling in the hippocampal pyramidal cells in the hypoxia-treated group; the number of mitochondria increased, the average cross-sectional area did not increase significantly, and the mitochondrial ridge structure was intact. The differences were explored.