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目的：建立肠道碘吸收速率模型，观察不同日龄大鼠的肠道碘吸收速率变化及其特点，为给婴幼儿合理、适宜地补碘提供基础资料。方法：Ｗｉｓｔａｒ成年大鼠２０只，雌雄各半，采用原位肠道灌流方法，建立肠道碘吸收速率模型。根据模型方法，观察出生后１３、１６、２１、３０、４５日龄幼鼠（每组１２只左右）空肠与回肠的碘吸收速率变化及其特点。结果：肠腔内灌流液碘浓度随时间的延长，早期呈快速下降，然后浓度降低速度减慢，该吸收特点符合二房室模型，肠腔内碘浓度的变化可用一双指数曲线数学式表达Ｘ１（ｔ）＝Ａｅ－αｔ＋Ｂｅ－βｔ。根据数学式计算出Ｋ１２、Ｋ２１、Ｋ０２值及快速相和慢速相的生物半减期。成年大鼠肠道碘吸收快速相生物半减期（ＦＰ１／２）约为２～３分钟，慢速相生物半减期（ＳＰ１／２）约为４０～６０分钟。成年雄鼠空肠碘吸收能力高于雌鼠，１３、１６、２１日龄雌鼠肠道碘吸收能力低于４５日龄鼠，但差异均无显著性。不同日龄雄鼠间肠道碘吸收速率未见规律性变化。结论：大鼠肠道碘吸收速率模型为二房室模型；大鼠空、回肠对碘的吸收速率很快；幼龄雌鼠吸收碘的能力略低，雄鼠未见年龄别变化；成年雌鼠肠道吸收碘的能力稍低于雄鼠。提示雌性易于发生相对缺碘
OBJECTIVE: To establish a model of intestinal iodine absorption rate and to observe the changes of intestinal iodine absorption rate and its characteristics in different age-old rats, so as to provide the basic information for proper and proper iodine supplementation in infants. Methods: Twenty adult Wistar rats, male and female, were divided into two groups. The model of intestinal iodine absorption was established by the method of intestinal perfusion. According to the model method, changes in iodine absorption rate and its characteristics in the jejunum and ileum of postnatal 13, 16, 21, 30, 45-day-old pups (each group of about 12 rats) were observed. Results: The concentration of iodine in intestine perfusion fluid increased rapidly with time and decreased rapidly in the early stage, and then the concentration decreased slowly. The absorption characteristic accorded with two-compartment model. The change of iodine concentration in intestine could be expressed by a pair of exponential curves. t) = Ae-αt + Be-βt. According to the mathematical formula to calculate the K12, K21, K02 value and fast phase and slow phase biological half-life reduction. Intestinal iodine absorption in adult rats is about 2 to 3 minutes for the fast-phase half-life (FP1 / 2) and about 60 to 60 minutes for the slow phase half-life (SP1 / 2). Iodine iodine absorption capacity of adult male rats was higher than that of female rats, but intestinal iodine absorption capacity of female rats at 13, 16 and 21 days was lower than that of 45-day old mice, but the difference was not significant. There was no regular change of intestinal iodine absorption rate between male and female rats of different ages. Conclusion: The intestinal iodine absorption rate model of rats is a two-compartment model; the absorption rate of iodine in the empty and ileum of rats is very fast; the ability of young females to absorb iodine is slightly lower; Intestinal absorption of iodine slightly lower than the male rats. Suggesting that the relative prone to iodine deficiency in females