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介绍了“四川联大Ⅰ型”（以下简称：ＳＵＵⅠ）管外流式（ＥＬＦ）中空纤维膜式氧合器的研制、设计、外形制做及离心封端等过程，重点介绍了中空纤维膜材料选择，膜肺离心封端的原理、材料、设备及方法，并对聚氨酯胶进行离心封端的具体步聚作了较详细的叙述。作者根据自身在国外与国内的研制经验，认为离心封端的关键在于：（１）中空纤维膜材料的质量及成束质量；（２）聚氨酯封端胶材料固化特性的掌握及料量计算；（３）反应温度控制；（４）气体排除；（５）转速的控制；（６）纤维束的安装；（７）脱模和切头的时间掌握等方面。作者用外购的材料和自己设计制造的离心封端机成功地制造了我国第一个管外流式（ＥＬＦ）中空纤维成人氧合器。ＳＵＵⅠ膜式氧合器的设计是作者在国外建立的交叉流式膜肺Ｏ２、ＣＯ２传递模型的具体应用。
Introduced the development, design, shape-making and centrifugal end-sealing processes of the “Sichuan United University-I type” (hereinafter referred to as SUU-I) tube outflow type (ELF) hollow fiber membrane oxygenator. The selection of hollow fiber membrane materials, the principles, materials, equipment and methods of membrane lung centrifugation, and the detailed step-by-step description of polyurethane sealant with centrifugal closure were described. Based on its own experience in foreign and domestic research, the author believes that the key to centrifugal closure is: (1) the quality and bundled quality of hollow fiber membrane materials; (2) mastering the curing characteristics of polyurethane end-capping materials and calculation of the amount of material; ( 3) reaction temperature control; (4) gas elimination; (5) speed control; (6) fiber bundle installation; (7) demoulding and cutting head time and other aspects. The authors successfully manufactured China’s first ELF hollow fiber adult oxygenator using purchased materials and a self-designed centrifugal tipping machine. The design of the SUU-I membrane oxygenator is the specific application of the O2 and CO2 delivery model of cross-flow membrane lung established by the author abroad.