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Das Gup ta et al Am J Hosp Pharm 1985; 42(3): 598 硫酸镁常与某些抗生素混用,以治疗妊娠子痫前期和子痫性毒血症,过去文献报道并未发现化学的和外观的配伍变化。但作者通过高效液相色谱(HPLC),用稳定性一指示测定法,研究了青霉素G钾P(0.5mg/ml)的稳定性确实受硫酸镁的影响。实验结果指出,在未加缓冲剂的青霉素溶液中有高浓度的硫酸镁(MgSO_1·7H_2O3～8mg/ml),(?)
Das Gupta et al Am J Hosp Pharm 1985; 42 (3): 598 Magnesium sulfate is often used in combination with certain antibiotics to treat pregnancy-induced preeclampsia and eclamptic sepsis. In the past, no chemical or cosmetic Compatibility changes. However, the authors investigated the stability of penicillin G potassium P (0.5 mg / ml) by magnesium sulfate by high performance liquid chromatography (HPLC) using a stability-indicative assay. The experimental results show that there is a high concentration of magnesium sulfate (MgSO 1 · 7H 2 O 3 ~ 8 mg / ml) in the unbuffered penicillin solution,