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探讨P16基因的表达与人胃癌组织类型的关系。方法：选取24例病理确诊的胃癌组织及相应正常胃粘膜组织，用蛋白质免疫印迹（Westernblot）做术检测p16基因在两种组织中的表达。结果：24例胃癌组织中，6例无p16基因表达的癌组织为低分化腺癌或印戒细胞癌；2例p16基因表达可疑；分化较高的5例p16基因表达增多；其余11例p16基因的表达同相应正常组织无区别。结论：p16基因在胃癌组织中的表达既可减低，也可增加，相当一部分胃癌组织p16基因的表达同相应正常组织无明显区别；p16基因表达减低的病例，其病理学诊断往往属于恶性程度较高的低分化腺癌或印戒细胞癌，可能与患者的预后有一定关系。
To investigate the relationship between P16 gene expression and human gastric cancer tissue types. Methods: Twenty-four gastric cancer tissues and corresponding normal gastric mucosa tissues were selected. Western blotting was used to detect the expression of p16 gene in both tissues. Results: Among the 24 cases of gastric carcinoma, 6 cases had poorly differentiated adenocarcinoma or signet ring cell carcinoma, 6 cases had p16 gene expression suspicious, 5 cases had higher differentiated p16 gene expression, and 11 cases had p16 Gene expression with the corresponding normal tissue without distinction. Conclusion: The expression of p16 gene in gastric cancer tissue can be reduced or increased, a considerable part of gastric cancer tissue p16 gene expression with the corresponding normal tissue no significant difference; p16 gene expression decreased cases, the pathological diagnosis often belongs to the degree of malignancy Highly differentiated adenocarcinoma or signet ring cell carcinoma may have a relationship with the patient’s prognosis.