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复发性阿弗它溃疡(RAU)是口腔常见疾病,发病率约10～20%,而且可出现在白塞氏病(BD)等具有多系统表现的炎性病变中。虽然BD的口腔溃疡在临床表现及组织学变化上与RAU的溃疡相同,但两者的具体联系还不清楚。诸多研究已提出了BD与RAU的免疫病理机制,提示RAU及BD患者最初有免疫异常而导致免疫调节的改变。人类T辅助细胞亚群根据交联的单克隆抗体的不同而分为两种不同的亚类,单抗4B_4定义的CD_4阳性亚类(辅助/诱导细胞),可为B细胞产生抗体提供帮助;与
Recurrent aphthous ulcer (RAU) is a common disease in the mouth with an incidence of about 10 to 20%, and it can occur in inflammatory lesions with multiple system manifestations such as Behcet’s disease (BD). Although BD’s oral ulcers have the same clinical and histological changes as RAU ulcers, the exact relationship between the two is still unclear. Numerous studies have proposed the immunopathological mechanism of BD and RAU, suggesting that there are initially immune abnormalities in patients with RAU and BD that lead to changes in immune regulation. Human T helper cell subpopulations are divided into two distinct subclasses based on cross-linked monoclonal antibodies, and CD4 positive subtypes defined by monoclonal antibody 4B_4 (helper/inducer cells) can provide help for B cells to produce antibodies; versus