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香叶木素(Diosmetin,Dio)是从柠檬酸(CitrusLimon)中提得的单体。笔者在实验中发现此单体有抗休克作用,但文献未见有任何药理作用报道,本文着重报道香叶木素对失血性休克猫的升压作用。1 Dio对失皿性休克猫血压的影响从股动脉放血至血压维持在5.33 kPa(40 mmHg).14只失血性休克猫等分2组,1 组血压稳定后Dio25 mg·kg~(-1)iv,记录2h内血压的变化情况,另组等量5％碳酸氢钠iv作为对照.结果Dio组净升压高峰值平均为13.9±2.6kPa,溶媒组为3.9±2.5 kPa(P<0.o1);2h内的净升血压,Dio组为10.6±2.1kPa,溶媒组为4.6±2.1kPa(P<0.o1)。
Diosmetin (Dio) is a monomer derived from CitrusLimon. I found in the experiment this monomer has anti-shock effect, but the literature did not find any pharmacological effects reported, this article focuses on the release of lignocellulose hemorrhagic shock cats boosting effect. The effect of Dio on the blood pressure of patients with undiagnosed shock cats. The blood pressure was maintained at 5.33 kPa (40 mmHg) from the femoral artery and 14 rats were randomly divided into 2 groups. One group was treated with Dio25 mg · kg -1 ) iv, the changes of blood pressure were recorded within 2h, and the other group was treated with 5% sodium bicarbonate iv as control.Results The average peak pressure increase of Dio group was 13.9 ± 2.6kPa and that of vehicle group was 3.9 ± 2.5kPa (P <0 .o1); 2h within the net rise in blood pressure, Dio group was 10.6 ± 2.1kPa, vehicle group was 4.6 ± 2.1kPa (P <0.o1).