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目的 探讨HLA DQA1基因多态性在中国汉人MG易感性中的作用。方法 运用PCR RFLP法进行HLA DQA1基因分型。结果 将MG病例组按不同胸腺组织、不同发病年龄结合性别进行分组与对照组比较 ,都有DQA1 0 30 1频率的明显增高 ,差异有显著性。结论 DQA1 0 30 1参与中国汉人胸腺增生型和小于 30岁发病的男性MG患者易感性。
Objective To investigate the role of HLA DQA1 gene polymorphism in the susceptibility to Chinese MG in Chinese. Methods HLA DQA1 genotyping was performed by PCR RFLP. Results The frequency of DQA1 0 30 1 in MG patients was significantly higher than that in control subjects according to different thymus tissues and different age of onset and gender. The difference was significant. Conclusions DQA1 0 30 1 is involved in the susceptibility of Chinese male patients with thymus hyperplasia and less than 30 years old.