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目的:了解我院药物不良反应(ADR)发生的情况及一般规律。方法:对大庆市第四医院2008年1月～2011年12月上报的203例ADR报告,按患者的年龄、性别、给药途径、药品类别、ADR累及器官或系统及临床表现等进行统计、分析。结果:203例ADR报告中涉及的药品共12类62种,其中抗微生物药引发的ADR最多,有87例(占42.9%);其次是中药注射剂35例(占17.2%);静脉给药引发的ADR例数最多,有168例(占82.76%);以皮肤及其附件损害最为常见,有57例(占28.1%)。结论:临床应重视和加强ADR监测和上报工作,以减少或避免ADR的发生,促进临床合理用药,保证患者用药安全。
Objective: To understand the incidence of adverse drug reactions (ADR) in our hospital and the general rules. Methods: 203 cases of ADR reported by the Fourth Hospital of Daqing from January 2008 to December 2011 were collected according to the patient’s age, sex, route of administration, drug category, ADR involved organ or system and clinical manifestations, analysis. Results: Of the 203 ADR cases, there were 62 kinds of drugs in 12 categories, of which 87 cases (42.9%) were antimicrobial-induced ADRs, followed by 35 cases (17.2%) of traditional Chinese medicine injections. After intravenous administration There were 168 cases (82.76%) of ADR cases, and 57 cases (28.1%) had the most damage to the skin and its accessories. Conclusion: Clinical should pay attention to and strengthen the work of ADR monitoring and reporting to reduce or avoid the occurrence of ADR, to promote clinical rational use of drugs to ensure the safety of patients.