目的 观察帕米膦酸二钠合并放疗对恶性肿瘤骨转移的疗效,并对其联合机制进行了探讨。方法 对54例恶性肿瘤骨转移患者在放疗中应用帕米膦酸二钠治疗,并设对照组(单用放疗)。结果 在54例患者中,止痛有效率98％,疼痛缓解时间缩短,对骨转移控制效果高于对照组。毒副反应轻微。结论 帕米膦酸二钠合并放疗治疗恶性肿瘤骨转移有良好的效果。 Objective To observe the curative effect of pamidronate disodium combined with radiotherapy on bone metastasis of malignant tumor and to explore its mechanism. Methods 54 cases of malignant bone metastases in the application of pamidronate in the treatment of radiotherapy, and the control group (with radiotherapy alone). Results In 54 patients, analgesic efficiency was 98%, pain relief time was shortened, and bone metastasis control effect was higher than that of control group. Toxicity minor. Conclusion Pamidronate combined with radiotherapy for the treatment of malignant bone metastases with good results.