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目的:探讨电针对慢性疲劳综合征(CFS)大鼠学习记忆能力及大鼠血清中肿瘤坏死因子-α (TNF-α)、白介素-10(IL-10)和干扰素-γ(IFN-γ)含量的影响.方法:SD大鼠36只,随机分为对照组、模型组、电针组各12只.电针组和模型组采用负重强迫游泳联合慢性应激刺激造模28 d,电针组于造模14 d后对大鼠进行电针治疗,选取双侧感觉区、百会穴、宁神穴,连续治疗14 d,模型组给予相同时间的捆绑,不予治疗.治疗结束后采用Morris水迷宫实验评价大鼠学习记忆能力,并用ELISA检测大鼠血清中TNF-α、IL-10和IFN-γ的变化情况.结果:与对照组相比,模型组大鼠平台潜伏期延长(P＜0.01),穿越平台次数减少(P＜0.01);与模型组相比,电针组大鼠平台潜伏期缩短(P＜0.01),穿越平台次数增多(P＜0.01).模型组大鼠的血清TNF-α和IL-10含量较对照组显著上升(P＜0.01),IFN-γ含量显著下降(P＜0.01);电针组大鼠的血清TNF-α和IL-10水平较模型组显著降低(P＜0.01),IFN-γ水平显著升高(P＜0.01).结论:电针可明显改善CFS大鼠的学习记忆能力,调节其血清炎性细胞因子水平.“,”Objective: To investigate the effects of electroacupuncture on the learning and memory capabilities and serum levels of tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), and interferon-γ (IFN-γ) in rats with chronic fatigue syndrome. Methods: Thirty-six male SD rats were randomly divided into the control group, model group, and electroacupuncture group, with 12 rats in each group. The electroacupuncture group and model group were subjected to forced weight-bearing swimming and chronic stress stimulation for 28 days. The electroacupuncture group was treated with electroacupuncture from the 14th day after modeling. The bilateral sensory area, Baihui point, and Ningshen point were selected for electroacupuncture, and continuous treatment was given for 14 days. The model group was bound for the same length of time but was not treated. After treatment, the learning and memory capabilities of rats were evaluated by the Morris Water Maze test. Blood was drawn and centrifuged to isolate serum, and changes in serum TNF-α, IL-10, and IFN-γ were detected by ELISA. Results: In the Morris water maze test, compared with that of the control group, the escape latency in the model group was prolonged (P<0.01) and the number of platform crossings was decreased (P<0.01). Compared with the model group, the escape latency in the electroacupuncture group was shortened (P<0.01) and the number of platform crossings increased (P<0.01). In addition, the serum levels of TNF-α and IL-10 were significantly increased and that of IFN-γ significantly decreased in the model group compared to those in the control group (all P<0.01). The serum levels of TNF-α and IL-10 were significantly decreased and that of IFN-γ significantly increased in the electroacupuncture group compared to those in the model group (all P<0.01). Conclusion: Electroacupuncture can significantly improve the learning and memory capability and regulate the serum inflammatory cytokine levels of rats with chronic fatigue syndrome .