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目的:观察中药大承气汤联合奥曲肽治疗重症急性胰腺炎临床疗效。方法:将纳入的76例重症急性胰腺炎患者按随机数字表法分为2组各38例,2组患者入院后均给予常规治疗,治疗组在常规治疗的基础上给予中药大承气汤联合奥曲肽治疗,对照组在常规治疗的基础上加用奥曲肽治疗,比较2组临床治疗效果。结果:临床疗效总有效率治疗组89.47%,对照组68.42%,2组临床疗效比较,差异有统计学意义(P<0.05);治疗组腹痛消失、腹胀消失、肠鸣音恢复、排气恢复及住院时间均短于对照组,2组间比较,差异均有统计学意义(P<0.05);且2组血清淀粉酶、脂肪酶、血白细胞及急性生理和慢性健康状况评估-Ⅱ(APACHE-Ⅱ)评分均有改善,治疗前后比较,差异均有统计学意义(P<0.05);且治疗组改善情况分别与对照组比较,差异均有统计学意义(P<0.05)。结论:中药大承气汤联合奥曲肽治疗重症胰腺炎临床疗效良好,能缓解患者临床症状,缩短住院时间,值得临床应用。
Objective: To observe the clinical efficacy of Dachengqi Decoction combined with octreotide in the treatment of severe acute pancreatitis. Methods: A total of 76 patients with severe acute pancreatitis were randomly divided into two groups of 38 patients according to random number table. The patients in both groups were given routine treatment after admission. The treatment group was given Dachengqi Decoction Octreotide treatment, the control group on the basis of conventional therapy plus octreotide treatment, the clinical efficacy of two groups were compared. Results: The total effective rate of clinical efficacy was 89.47% in the treatment group and 68.42% in the control group. There was significant difference between the two groups in clinical curative effect (P <0.05). The abdominal pain disappeared, the abdominal distension disappeared, the bowel sounds recovered and the exhaust gas recovered (P <0.05). The serum amylase, lipase, leucocyte and acute physiology and chronic health status assessment-Ⅱ (APACHE-Ⅱ) in two groups were significantly higher than those in the control group (P <0.05). The improvement of the treatment group was statistically significant (P <0.05) compared with the control group, respectively. Conclusion: The traditional Chinese medicine Dachengqi Decoction combined with octreotide in the treatment of severe pancreatitis has a good clinical curative effect, which can relieve the clinical symptoms and shorten the length of hospital stay, which is worthy of clinical application.