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目的 :探讨小儿中枢神经系统感染时白介素 8(IL 8)、粒细胞集落刺激因子 (G CSF)的变化。方法 :用ELISA法检测 91例中枢神经系统感染患儿中的 5 9例病毒性脑炎或脑膜脑炎 (Vm&Ve)患儿、2 2例化脓性脑膜炎患儿 (Pm)和 10例结核性脑膜炎患儿 (Tm) ,并以 2 1例非神经系统疾病患儿的脑脊液、血清G CSF和IL 8活性作为对照。结果 :患儿组脑脊液IL 8明显高于对照组 (P <0 .0 5 ) ,但患儿组间差异无显著性。G CSF各组间差异无显著性。结论 :IL 8在中枢神经系统感染发病中起作用 ,但IL 8、G CSF的检测无鉴别诊断价值。
Objective: To investigate the changes of interleukin 8 (IL 8) and granulocyte colony stimulating factor (G CSF) in children with central nervous system infection. Methods: Ninety-nine children with viral encephalitis or meningoencephalitis (Vm & Ve), 22 children with purulent meningitis (Pm), and 10 children with tuberculosis Children with meningitis (Tm) were enrolled in this study. Cerebrospinal fluid (CSF), serum G CSF and IL-8 activities in children with non-neurological diseases were used as controls. Results: The level of IL 8 in cerebrospinal fluid in children was significantly higher than that in control group (P <0.05), but there was no significant difference between the two groups. There was no significant difference between G CSF groups. Conclusion: IL 8 plays a role in the pathogenesis of central nervous system infection, but the detection of IL 8 and G CSF has no diagnostic value.