弯曲菌是一种全球普遍关注的引起人兽共患病的病原菌。由于临床治疗和养殖业的不合理使用抗生素,导致弯曲菌的耐药性日益严重。核糖体靶位点突变、核糖体蛋白变构和细胞膜上外排系统改变是弯曲菌对大环内酯类抗生素耐药的主要原因。就弯曲菌对大环内酯类抗生素的耐药现状和耐药机制进行综述。 Campylobacter is a common cause of zoonosis in the world. Due to the unreasonable use of antibiotics in clinical treatment and aquaculture, Campylobacter is increasingly becoming more drug-resistant. Ribosomal target site mutations, ribosomal protein allosteric and cell membrane on the system changes in the outer membrane of Campylobacter macrolides antibiotic resistance is the main reason. The current status and mechanism of drug resistance of macrolide antibiotics to Campylobacter were summarized.