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目的制定适合老年高血压患者的高风险用药目录,保证老年高血压患者用药安全。方法结合我国降压药品上市情况,采用循证方法查阅药品说明书、相关指南及中英文数据库中的相关文献,评价药物安全性,筛选出对老年高血压患者风险较高的药物并整理该类药物的风险点及用药建议,形成初始目录并制成第一轮调查问卷。专家论证过程采用德尔菲法征询专家意见,经过两轮函询根据专家反馈意见形成最终目录,即为老年高血压患者高风险用药目录。结果经过循证评价,共遴选出27个高风险药物、113个风险点及45条用药建议,形成初始目录;初始目录经两轮德尔菲法专家函询论证,最终遴选出氢氯噻嗪、硝苯地平、维拉帕米、哌唑嗪、利血平、可乐定6个高风险药物、12个风险点及12条用药建议制成最终目录。结论初步制定了适合我国老年高血压患者的高风险用药目录,促进老年高血压患者合理用药,降低用药风险。
Objective To develop a high-risk medication list suitable for elderly hypertensive patients to ensure drug safety for elderly hypertensive patients. Methods Combined with the listing of antihypertensive drugs in China, we used the evidence - based method to consult the drug specification, relevant guidelines and related articles in Chinese and English databases to evaluate the safety of drugs and screened out the drugs at higher risk for elderly hypertensive patients and sorted out the drugs Risk points and medication recommendations, the formation of the initial directory and made the first round of questionnaires. Delphi expert consultative process expert advice, after two rounds of consultation based on feedback from experts to form the final directory, that is, high-risk medication for elderly hypertensive directory. Results After evidence-based evaluation, a total of 27 high-risk drugs, 113 risk points and 45 drug recommendations were selected to form the initial list. The initial list was submitted through two rounds of Delphinian expert letter of inquiry. Finally, hydrochlorothiazide, nifedipine , Verapamil, prazosin, reserpine, clonidine 6 high-risk drugs, 12 risk points and 12 drug recommendations made the final directory. Conclusion The preliminary list of high-risk prescriptions suitable for elderly hypertensive patients in our country has been preliminarily formulated to promote rational drug use in elderly hypertensive patients and reduce the risk of medication.